Gliding protein

Function

Gliding protein or Mutual gliding-motility protein or Gliding motility protein (MglA and MglB). MglA is related to GTPase and is required for the normal operation of adventurous and social motility and multicellular development of some bacteria^[1]. In Myxococcus xanthus MglA regulates the movement of the bacteria on surfaces. MglB is MglA cognate GTPase activating protein^[2].

Structural highlights

The 3D structure of the complex of and shows their ^[3]. . Water molecules are shown as red spheres. The bound in MglA. .

Se-Met MglA (magenta) complex with MglB (green, pink), GTP-γS, Mg+2 ion (green) and sulfate (PDB code 6izw).

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3D structures of gliding protein3D structures of gliding protein

Updated on 04-August-2021

ReferencesReferences

↑ Patryn J, Allen K, Dziewanowska K, Otto R, Hartzell PL. Localization of MglA, an essential gliding motility protein in Myxococcus xanthus. Cytoskeleton (Hoboken). 2010 May;67(5):322-37. doi: 10.1002/cm.20447. PMID:20196075 doi:http://dx.doi.org/10.1002/cm.20447
↑ Szadkowski D, Harms A, Carreira LAM, Wigbers M, Potapova A, Wuichet K, Keilberg D, Gerland U, Sogaard-Andersen L. Spatial control of the GTPase MglA by localized RomR-RomX GEF and MglB GAP activities enables Myxococcus xanthus motility. Nat Microbiol. 2019 Aug;4(8):1344-1355. doi: 10.1038/s41564-019-0451-4. Epub 2019, May 20. PMID:31110363 doi:http://dx.doi.org/10.1038/s41564-019-0451-4
↑ Baranwal J, Lhospice S, Kanade M, Chakraborty S, Gade PR, Harne S, Herrou J, Mignot T, Gayathri P. Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility. PLoS Biol. 2019 Sep 27;17(9):e3000459. doi: 10.1371/journal.pbio.3000459., eCollection 2019 Sep. PMID:31560685 doi:http://dx.doi.org/10.1371/journal.pbio.3000459

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Michal Harel, Alexander Berchansky

[1] Patryn J, Allen K, Dziewanowska K, Otto R, Hartzell PL. Localization of MglA, an essential gliding motility protein in Myxococcus xanthus. Cytoskeleton (Hoboken). 2010 May;67(5):322-37. doi: 10.1002/cm.20447. PMID:20196075 doi:http://dx.doi.org/10.1002/cm.20447

[2] Szadkowski D, Harms A, Carreira LAM, Wigbers M, Potapova A, Wuichet K, Keilberg D, Gerland U, Sogaard-Andersen L. Spatial control of the GTPase MglA by localized RomR-RomX GEF and MglB GAP activities enables Myxococcus xanthus motility. Nat Microbiol. 2019 Aug;4(8):1344-1355. doi: 10.1038/s41564-019-0451-4. Epub 2019, May 20. PMID:31110363 doi:http://dx.doi.org/10.1038/s41564-019-0451-4

[3] Baranwal J, Lhospice S, Kanade M, Chakraborty S, Gade PR, Harne S, Herrou J, Mignot T, Gayathri P. Allosteric regulation of a prokaryotic small Ras-like GTPase contributes to cell polarity oscillations in bacterial motility. PLoS Biol. 2019 Sep 27;17(9):e3000459. doi: 10.1371/journal.pbio.3000459., eCollection 2019 Sep. PMID:31560685 doi:http://dx.doi.org/10.1371/journal.pbio.3000459

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