Hemolysin

Function

Hemolysin (HL) is exotoxin from bacteria which causes lysis of red blood cells^[1].

alpha-hemolysin is a transmembrane pore-forming heptameric molecule^[2]. See details for in Pore forming toxin, α-hemolysin.
delta-hemolysin is a 26 amino acid peptide from the bacterium Staphylococcus exhibiting antimicrobial activity against Legionerlla ^[3].

See details of hemolysin E in Molecular Playground/ClyA.

For toxins in Proteopdia see Toxins.

Relevance

HL acts as a virulence factor in the pathogenesis of invasive infections^[4].

3D Printed Physical Model of Hemolysin

Shown below is a 3D printed physical model of Hemolysin. The model is shown in alpha carbon backbone format with each chain colored uniquely.

The MSOE Center for BioMolecular Modeling

The MSOE Center for BioMolecular Modeling uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our Model Gallery.

3D Structures of hemolysin

Hemolysin 3D structures

ReferencesReferences

↑ Mestre MB, Fader CM, Sola C, Colombo MI. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells. Autophagy. 2010 Jan;6(1):110-25. PMID:20110774
↑ Song L, Hobaugh MR, Shustak C, Cheley S, Bayley H, Gouaux JE. Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science. 1996 Dec 13;274(5294):1859-66. PMID:8943190
↑ Verdon J, Girardin N, Lacombe C, Berjeaud JM, Héchard Y. delta-hemolysin, an update on a membrane-interacting peptide. Peptides. 2009 Apr;30(4):817-23. PMID:19150639 doi:10.1016/j.peptides.2008.12.017
↑ Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec;10(12):575-80. PMID:12564994

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Alexander Berchansky, Michal Harel, Mark Hoelzer

[1] Mestre MB, Fader CM, Sola C, Colombo MI. Alpha-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells. Autophagy. 2010 Jan;6(1):110-25. PMID:20110774

[2] Song L, Hobaugh MR, Shustak C, Cheley S, Bayley H, Gouaux JE. Structure of staphylococcal alpha-hemolysin, a heptameric transmembrane pore. Science. 1996 Dec 13;274(5294):1859-66. PMID:8943190

[3] Verdon J, Girardin N, Lacombe C, Berjeaud JM, Héchard Y. delta-hemolysin, an update on a membrane-interacting peptide. Peptides. 2009 Apr;30(4):817-23. PMID:19150639 doi:10.1016/j.peptides.2008.12.017

[4] Nizet V. Streptococcal beta-hemolysins: genetics and role in disease pathogenesis. Trends Microbiol. 2002 Dec;10(12):575-80. PMID:12564994

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