Galactose mutarotase
<StructureSection load='1ns0' size='350' side='right' caption='Structure of galactose mutarotase complex with α-D-galactose and Na+ ion (purple) (PDB entry 1ns0)' scene='57/572275/Cv/1'>
FunctionFunction
Galactose mutarotase (GalM) reversibly converts α-lactose to β-lactose. GalM catalyzes the first step in galactose metabolism[1].
Structural highlightsStructural highlights
From extensive study of mutations in Lactococcus lactis GalM complexes with various sugars it was found that residues H170 and E304 are critical for the active site binding.
. Water molecules shown as red spheres.
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3D structures of galactose mutarotase3D structures of galactose mutarotase
Updated on 30-July-2020
1snz – hGalM – human
1so0 - hGalM (mutant) + α-D-galactose
1l7j – LlGalM – Lactococcus lactis
1l7k, 1ns0, 1ns2, 1ns8, 1nsu, 1nsx – LlGalM (mutant) + α-D-galactose
1mmu, 1ns4, 1ns7, 1nsr, 1nss, 1nsv – LlGalM (mutant) + β-D-glucose
1nsz – LlGalM (mutant) + α-D-glucose
1mmx – LlGalM (mutant) + α-L-fuccose
1mmy – LlGalM (mutant) + D-quinovose
1mmz – LlGalM (mutant) + β-L-arabinose
1mn0 – LlGalM (mutant) + D-xylose
1nsm – LlGalM (mutant) + α-D-galactose + β-D-galactose
1lur – GalM – Caenorhabditis elegans
3mwx, 4bze - BsGalM – Bacillus subtilis
4bzf - BsGalM + trehalose
4bzg - BsGalM + maltose
4bzh - BsGalM + trehalose + maltose
3nre – GalM – Escherichia coli