File:Schematic representation of APP processing.jpg

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Schematic_representation_of_APP_processing.jpg ‎(409 × 467 pixels, file size: 113 KB, MIME type: image/jpeg)

An Alzheimer disease is responsible for the most comon form of dementia among old people.Causes of this disease are not clear but genes and environmental factors seem to play a major role. It is characterized by extensive neuronal death, shrinkage of the brain and also the presence of amyloid plaques into the brain. These plaques are concentrated with Aβ peptide which results from the anormal cleavage of APP by successive action of the β and γ secretases, represented here.

[1]

ReferencesReferences

  1. ↑ Khalifa NB, Van Hees J, Tasiaux B, Huysseune S, Smith SO, Constantinescu SN, Octave JN, Kienlen-Campard P. What is the role of amyloid precursor protein dimerization? Cell Adh Migr. 2010 Apr-Jun;4(2):268-72. Epub 2010 Apr 11. PMID:20400860

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current15:42, 5 January 2013Thumbnail for version as of 15:42, 5 January 2013409 × 467 (113 KB)Andréa Mc Cann (talk | contribs)

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