Ferripyoverdine receptor

Function

Ferripyoverdine receptor (Fpv) is an outer-membrane receptor of Pseudomonas aeruginosa which uptakes the pyoverdine-Fe+3 siderophore secreted by the bacteria under conditions of iron limitation to scavange Fe+3^[1].

Structural highlights

The bound to a cyclic octapeptide containing L and D residues^[2]. .

Ferripyoverdine receptor (green) complex with pyoverdine (wheat) and sulfate (PDB code 1xkh)

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3D structures of ferripyoverdine receptor3D structures of ferripyoverdine receptor

Updated on 18-March-2019

1xkh, 2iah – PaFpv + pyoverdine + Fe – Pseudomonas aeruginosa
2w16, 2w6t, 2w6u, 2w76, 2w77, 2w78 – PaFpv + non-cognate pyoverdine + Fe
2w75 – PaFpv + non-cognate pyoverdine
2o5p – PaFpv
5odw – PaFpv + pyocin-S2

ReferencesReferences

↑ Ghysels B, Dieu BT, Beatson SA, Pirnay JP, Ochsner UA, Vasil ML, Cornelis P. FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa. Microbiology. 2004 Jun;150(Pt 6):1671-80. PMID:15184553 doi:http://dx.doi.org/10.1099/mic.0.27035-0
↑ Cobessi D, Celia H, Folschweiller N, Schalk IJ, Abdallah MA, Pattus F. The crystal structure of the pyoverdine outer membrane receptor FpvA from Pseudomonas aeruginosa at 3.6 angstroms resolution. J Mol Biol. 2005 Mar 18;347(1):121-34. Epub 2005 Jan 21. PMID:15733922 doi:10.1016/j.jmb.2005.01.021

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Michal Harel, Alexander Berchansky, Joel L. Sussman

[1] Ghysels B, Dieu BT, Beatson SA, Pirnay JP, Ochsner UA, Vasil ML, Cornelis P. FpvB, an alternative type I ferripyoverdine receptor of Pseudomonas aeruginosa. Microbiology. 2004 Jun;150(Pt 6):1671-80. PMID:15184553 doi:http://dx.doi.org/10.1099/mic.0.27035-0

[2] Cobessi D, Celia H, Folschweiller N, Schalk IJ, Abdallah MA, Pattus F. The crystal structure of the pyoverdine outer membrane receptor FpvA from Pseudomonas aeruginosa at 3.6 angstroms resolution. J Mol Biol. 2005 Mar 18;347(1):121-34. Epub 2005 Jan 21. PMID:15733922 doi:10.1016/j.jmb.2005.01.021

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