Erythrocyte binding antigen

Erythrocyte binding antigen or Duffy receptor (EBA) is a Plasmodium ligand which binds to erythrocytes. Some strains are dependent on sialic acid for binding^[1].

EBA-175 is a Plamodium ligand that binds to human erythrocytes glycophorin A in a sialic acid-dependent manner^[2].
EBA-140 is a Plamodium ligand that binds to human erythrocytes glycophorin C ^[3]. For more details see Malaria Parasite Plasmodium falciparum Erythrocyte Binding Antigen 140.
Duffy receptor is a glycogen receptor for chemicals secreted by blood cells and for Plamodium ligand ^[4].

EBA region II (mutant) complex with sulfate and Cl- ion (PDB code 1zro)

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3D Structures of erythrocyte binding antigen3D Structures of erythrocyte binding antigen

Updated on 19-June-2024

ReferencesReferences

↑ Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276
↑ Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4796-801. PMID:12672957 doi:10.1073/pnas.0730883100
↑ Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276
↑ Chootong P, McHenry AM, Ntumngia FB, Sattabongkot J, Adams JH. The association of Duffy binding protein region II polymorphisms and its antigenicity in Plasmodium vivax isolates from Thailand. Parasitol Int. 2014 Dec;63(6):858-64. PMID:25108177 doi:10.1016/j.parint.2014.07.014

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Michal Harel

[1] Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276

[2] Duraisingh MT, Maier AG, Triglia T, Cowman AF. Erythrocyte-binding antigen 175 mediates invasion in Plasmodium falciparum utilizing sialic acid-dependent and -independent pathways. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4796-801. PMID:12672957 doi:10.1073/pnas.0730883100

[3] Lin DH, Malpede BM, Batchelor JD, Tolia NH. Crystal and Solution Structures of Plasmodium falciparum Erythrocyte-binding Antigen 140 Reveal Determinants of Receptor Specificity during Erythrocyte Invasion. J Biol Chem. 2012 Oct 26;287(44):36830-6. doi: 10.1074/jbc.M112.409276. Epub 2012, Sep 18. PMID:22989878 doi:10.1074/jbc.M112.409276

[4] Chootong P, McHenry AM, Ntumngia FB, Sattabongkot J, Adams JH. The association of Duffy binding protein region II polymorphisms and its antigenicity in Plasmodium vivax isolates from Thailand. Parasitol Int. 2014 Dec;63(6):858-64. PMID:25108177 doi:10.1016/j.parint.2014.07.014

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