Dehydroquinase

Function

Dehydroquinase (DHQD) catalyzes the conversion of 3-hydroquinate to 3-hydroshikimate. DHQD is part of the shikimate pathway by which bacteria synthesize the aromatic amino acids. There are 2 types of DHQD found in different organisms. They differ in their sequence and structure. ^[1]

Relevance

Inhibitors of DHQD are potential bacteriocides.^[2]

Structural highlights

The structure of dehydroquinase type I complex with quinate shows . The binding of quinate in .^[3] .

3D structures of dehydroquinase

Dehydroquinase 3D structures

Structure of dehydroquinase type I complex with quinate and Ni+2 ion (PDB entry 4gui)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907
↑ Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002
↑ Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31. PMID:24437575 doi:http://dx.doi.org/10.1021/bi4015506

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Michal Harel, Alexander Berchansky

[1] Herrmann KM. The Shikimate Pathway: Early Steps in the Biosynthesis of Aromatic Compounds. Plant Cell. 1995 Jul;7(7):907-919. PMID:12242393 doi:http://dx.doi.org/10.1105/tpc.7.7.907

[2] Dias MV, Snee WC, Bromfield KM, Payne R, Palaninathan SK, Ciulli A, Howard NI, Abell C, Sacchettini JC, Blundell TL. Structural investigation of inhibitor designs targeting 3-dehydroquinate dehydratase from the shikimate pathway of Mycobacterium tuberculosis. Biochem J. 2011 Mar 17. PMID:21410435 doi:10.1042/BJ20110002

[3] Light SH, Antanasijevic A, Krishna SN, Caffrey M, Anderson WF, Lavie A. Crystal structures of type I dehydroquinate dehydratase in complex with quinate and shikimate suggest a novel mechanism of Schiff base formation. Biochemistry. 2014 Feb 11;53(5):872-80. doi: 10.1021/bi4015506. Epub 2014 Jan 31. PMID:24437575 doi:http://dx.doi.org/10.1021/bi4015506

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