Dehaloperoxidase

Dehaloperoxidase (DHP) is a heme-containing globin possessing peroxidase enzymatic activity. DHP catalyzes the peroxide-dependent dehalogenation of halophenol. DHP A and DHP B are isoenzymes of DHP.^[1]

Structural highlights

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3D structures of dehaloperoxidase

Dehaloperoxidase 3D structures

Dehaloperoxidase heme-containing dimer complex with tribromophenol, O2 and sulfate ions (PDB entry 4fh6)

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ReferencesReferences

↑ Barrios DA, D'Antonio J, McCombs NL, Zhao J, Franzen S, Schmidt AC, Sombers LA, Ghiladi RA. Peroxygenase and oxidase activities of dehaloperoxidase-hemoglobin from Amphitrite ornata. J Am Chem Soc. 2014 Jun 4;136(22):7914-25. doi: 10.1021/ja500293c. Epub 2014 May , 21. PMID:24791647 doi:http://dx.doi.org/10.1021/ja500293c
↑ Zhao J, de Serrano VS, Zhao J, Le PD, Franzen S. Structural and kinetic study of an internal substrate binding site of dehaloperoxidase-hemoglobin A from Amphitrite ornata. Biochemistry. 2013 Mar 12. PMID:23480178 doi:http://dx.doi.org/10.1021/bi301307f

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Michal Harel, Alexander Berchansky

[1] Barrios DA, D'Antonio J, McCombs NL, Zhao J, Franzen S, Schmidt AC, Sombers LA, Ghiladi RA. Peroxygenase and oxidase activities of dehaloperoxidase-hemoglobin from Amphitrite ornata. J Am Chem Soc. 2014 Jun 4;136(22):7914-25. doi: 10.1021/ja500293c. Epub 2014 May , 21. PMID:24791647 doi:http://dx.doi.org/10.1021/ja500293c

[2] Zhao J, de Serrano VS, Zhao J, Le PD, Franzen S. Structural and kinetic study of an internal substrate binding site of dehaloperoxidase-hemoglobin A from Amphitrite ornata. Biochemistry. 2013 Mar 12. PMID:23480178 doi:http://dx.doi.org/10.1021/bi301307f

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