Choline kinase

Function

Choline kinase (CK) catalyzes the conversion of choline and ATP to phosphocholine and ADP. CK is part of phosphatidylcholine biosynthesis.

Disease

Overexpression of CK α1 was found in various types of cancer cells. This can aid in promoting cancer cells survival and growth. CK α1 is used as cancer biomarker and anticancer drug target.

Relevance

Structural highlights

The choline binds to CK in a (PDB code 2ckq; Hydrophobic, Polar) and the (PDB code 2ckp). ^[1]

3D structures of choline kinase

Choline kinase 3D structures

Structure of human choline kinase α2 complex with phosphocholine (PDB code 2ckq).

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Malito E, Sekulic N, Too WC, Konrad M, Lavie A. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol. 2006 Nov 24;364(2):136-51. Epub 2006 Sep 3. PMID:17007874 doi:10.1016/j.jmb.2006.08.084

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Malito E, Sekulic N, Too WC, Konrad M, Lavie A. Elucidation of human choline kinase crystal structures in complex with the products ADP or phosphocholine. J Mol Biol. 2006 Nov 24;364(2):136-51. Epub 2006 Sep 3. PMID:17007874 doi:10.1016/j.jmb.2006.08.084

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