Cholesterol oxidase

Function Cholesterol oxidase (COX) catalyzes the conversion of cholesterol and molecular oxygen to Colest-4-en-3-one and hydrogen peroxide. COX uses FAD as a cofactor. COX I binds FAD non-covalently whereas COX II binds FAD covalently. Relevance COX is used as a biosensor for the detection of cholesterol in blood serum and food. Structural highlights There are predominantly hydrophobic/non-polar residues in (Hydrophobic, Polar) in COX. (PDB entry 1coy). Water molecules are shown as red spheres. .

spinqualitylabelsall models Cholesterol oxidase complex with steroid substrate (PDB entry 1coy) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structure of cholesterol oxidase3D structure of cholesterol oxidase

Updated on 12-May-2019

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• Cholesterol oxidase
  • 3cox, 1i19 – BsCOX – Brevibacterium sterolicum
    
  • 1b4v, 1mxt, 1n1p, 1n4u, 1n4v, 1n4w, 2gew, 4u2l, 4u2s, 4u2t, 5kwf, 4xxg, 4xwr, 4rek – StCOX – Streptomyces
    
  • 1b8s, 1cbo, 1cc2, 1ijh, 3b6d, 3cnj, 3gyi, 3gyj – StCOX (mutant)
    
  • 3js8 – COX – Chromobacterium
    
• Cholesterol oxidase complex
  • 1coy, 3cox – BsCOX + steroid
    
  • 3b3r - StCOX (mutant) + glycerol