Catechol O-methyltransferase

Function Catechol O-methyltransferase (COMT) methylates catecholamines like dopamine, epinephrine and norepinephrine. The cofactor S-adenosyl-L-methionine (SAM) serves as the methyl donor in the reaction and is converted to to S-adenosyl-L-homocysteine (SAH) by the reaction. For more details see Student Projects for UMass Chemistry 423 Spring 2012-6. Relevance The Parkinson Disease drug levodopa is a substrate of COMT and COMT inhibitors like entacapone are used with levodopa in the disease treatment. Structural highlights (PDB entry 3a7e). Water molecule is shown as red sphere. 3D Structures of catechol O-methyltransferase Catechol O-methyltransferase 3D structures

spinqualitylabelsall models Structure of human catechol O-methyltransferase complex with SAM and dinitrocatechol (PDB entry 3a7e) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image