Ascorbate peroxidase

Function

Ascorbate peroxidase (APX) catalyzes the conversion of ascorbate and hydrogen peroxide to dehydroascorbate and water thus detoxifying hydrogen peroxide. APX is involved in the glutathione-ascorbate cycle. APX is accumulated in plants in response to heat and drought stress. APX contains a heme group.

Relevance

APX is part of plants antioxidant defense. APX converts H2O2 to water using ascorbate as an electron donor. APX is used in electron microscopy as a genetic tag which can be stained independently of light activation.

Structural highlights

The of APX contains a and confers stability to the Fe state in the heme. ^[1]

3D structures of ascorbate peroxidase

Ascorbate peroxidase 3D structures

Soybean heme-containing ascorbate peroxidase complex with ascorbate and Na+ ion (purple), 1oaf

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Sharp KH, Mewies M, Moody PC, Raven EL. Crystal structure of the ascorbate peroxidase-ascorbate complex. Nat Struct Biol. 2003 Apr;10(4):303-7. PMID:12640445 doi:http://dx.doi.org/10.1038/nsb913

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Michal Harel, Alexander Berchansky

[1] Sharp KH, Mewies M, Moody PC, Raven EL. Crystal structure of the ascorbate peroxidase-ascorbate complex. Nat Struct Biol. 2003 Apr;10(4):303-7. PMID:12640445 doi:http://dx.doi.org/10.1038/nsb913

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