Antigen 85

Function Antigens 85A, 85B and 85C posses mycolyltransferase activity and generate trehalose dimycolate which is an essential envelope lipid for Mycobacterium tuberculosis virulence. Inhibition of these enzymes hinders growth of the bacteria. The three enzymes show very high sequence identity (68-79%). Disease Antigen 85 proteins levels are elevated in tuberculosis patients. Structural highlights The 3D structures of the 3 antigens show that their active sites are virtually identical indicating that they share the same substrate. However, residues at the surface of the enzymes are different. . 3D Structures of antigen 85 Antigen 85 3D structures

spinqualitylabelsall models Antigen 85C complex with detergent octylthioglucoside (PDB code 1va5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image