Anti-silencing factor

Function

Anti-silencing factor (ASF) or histone chaperone assits in chromatin assembly and remodeling during replication, transcription activation and gene silencing. ASF cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly and with histone regulatory homolog A (HIRA) to promote replication-independent assembly.^[1]

Structural highlights

ASF has an 80 residue segment which binds RNA at the N-terminal and a C-terminal which is composed of 80% Ser and Arg.

3D structures of anti-silencing factor

Anti-silencing factor 3D structures

Structure of yeast anti-silencing factor complex with Br- ions (PDB entry 1roc)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, Adams PD, Marmorstein R. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006 Oct;13(10):921-9. Epub 2006 Sep 17. PMID:16980972 doi:10.1038/nsmb1147

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Tang Y, Poustovoitov MV, Zhao K, Garfinkel M, Canutescu A, Dunbrack R, Adams PD, Marmorstein R. Structure of a human ASF1a-HIRA complex and insights into specificity of histone chaperone complex assembly. Nat Struct Mol Biol. 2006 Oct;13(10):921-9. Epub 2006 Sep 17. PMID:16980972 doi:10.1038/nsmb1147

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