Agrin

Function Agrin (Agr) is involved in the embryogenesis of the neuromuscular junction. It is involved in the aggregation of acetylcholine receptors. Relevance Agr is an inducer of mammalian heart regeneration. Disease Agr is overexpressed in brains of Alzheimer Disease patients. Agr is associated with myasthenic syndrome. Structural highlights Agr N-terminal domain binds laminin. The C-terminal of Agr has 3 laminin-like globular domains (LMB) G1-G3 and 4 epidermal growth factor-like domains. Agr binds heparan sulfate post-translationally. Other Agr domains are: Kazal type serine protease inhibitor. 3D Structures of Agrin Agrin 3D structures

spinqualitylabelsall models Chicken agrin (PDB code 3i70). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image