9jka

Human VANGL2 in complex with a PK1 peptide (residues 745-790)Human VANGL2 in complex with a PK1 peptide (residues 745-790)

Structural highlights

9jka is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.5Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

VANG2_HUMAN Isolated anencephaly;Isolated exencephaly. The disease is caused by variants affecting the gene represented in this entry.

Function

VANG2_HUMAN Involved in the control of early morphogenesis and patterning of both axial midline structures and the development of neural plate. Plays a role in the regulation of planar cell polarity, particularly in the orientation of stereociliary bundles in the cochlea. Required for polarization and movement of myocardializing cells in the outflow tract and seems to act via RHOA signaling to regulate this process. Required for cell surface localization of FZD3 and FZD6 in the inner ear (By similarity).[UniProtKB:Q91ZD4]

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