Intact V-ATPase State 2 in synaptophysin knock-out isolated synaptic vesiclesIntact V-ATPase State 2 in synaptophysin knock-out isolated synaptic vesicles

Structural highlights

9brs is a 14 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 4.4Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VATE1_MOUSE Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).[UniProtKB:P36543]

9brs, resolution 4.40Å

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OCA