8ze2

Drosophila melanogaster gustatory receptor 64a(Gr64a) in Sucrose-bound stateDrosophila melanogaster gustatory receptor 64a(Gr64a) in Sucrose-bound state

Structural highlights

8ze2 is a 4 chain structure with sequence from Drosophila melanogaster. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.57Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GR64A_DROME One of the few identified sugar gustatory receptors identified so far and which promotes the starvation-induced increase of feeding motivation. Required in combination with Gr64f to detect sucrose, maltose, and glucose.^[1] ^[2] ^[3] ^[4] ^[5] ^[6] ^[7]

References

↑ Jiao Y, Moon SJ, Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14110-5. PMID:17715294 doi:10.1073/pnas.0702421104
↑ Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr genes underlie sugar reception in Drosophila. Neuron. 2007 Nov 8;56(3):503-16. PMID:17988633 doi:10.1016/j.neuron.2007.10.024
↑ Jiao Y, Moon SJ, Wang X, Ren Q, Montell C. Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 2008 Nov 25;18(22):1797-801. PMID:19026541 doi:10.1016/j.cub.2008.10.009
↑ Dus M, Min S, Keene AC, Lee GY, Suh GS. Taste-independent detection of the caloric content of sugar in Drosophila. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11644-9. PMID:21709242 doi:10.1073/pnas.1017096108
↑ Nishimura A, Ishida Y, Takahashi A, Okamoto H, Sakabe M, Itoh M, Takano-Shimizu T, Ozaki M. Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster. J Neurogenet. 2012 Jun;26(2):206-15. PMID:22794108 doi:10.3109/01677063.2012.694931
↑ Mishra D, Miyamoto T, Rezenom YH, Broussard A, Yavuz A, Slone J, Russell DH, Amrein H. The molecular basis of sugar sensing in Drosophila larvae. Curr Biol. 2013 Aug 5;23(15):1466-71. PMID:23850280 doi:10.1016/j.cub.2013.06.028
↑ Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, Guo J. Structural basis for sugar perception by Drosophila gustatory receptors. Science. 2024 Feb 23;383(6685):eadj2609. PMID:38305684 doi:10.1126/science.adj2609

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OCA

[1] Jiao Y, Moon SJ, Montell C. A Drosophila gustatory receptor required for the responses to sucrose, glucose, and maltose identified by mRNA tagging. Proc Natl Acad Sci U S A. 2007 Aug 28;104(35):14110-5. PMID:17715294 doi:10.1073/pnas.0702421104

[2] Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr genes underlie sugar reception in Drosophila. Neuron. 2007 Nov 8;56(3):503-16. PMID:17988633 doi:10.1016/j.neuron.2007.10.024

[3] Jiao Y, Moon SJ, Wang X, Ren Q, Montell C. Gr64f is required in combination with other gustatory receptors for sugar detection in Drosophila. Curr Biol. 2008 Nov 25;18(22):1797-801. PMID:19026541 doi:10.1016/j.cub.2008.10.009

[4] Dus M, Min S, Keene AC, Lee GY, Suh GS. Taste-independent detection of the caloric content of sugar in Drosophila. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11644-9. PMID:21709242 doi:10.1073/pnas.1017096108

[5] Nishimura A, Ishida Y, Takahashi A, Okamoto H, Sakabe M, Itoh M, Takano-Shimizu T, Ozaki M. Starvation-induced elevation of taste responsiveness and expression of a sugar taste receptor gene in Drosophila melanogaster. J Neurogenet. 2012 Jun;26(2):206-15. PMID:22794108 doi:10.3109/01677063.2012.694931

[6] Mishra D, Miyamoto T, Rezenom YH, Broussard A, Yavuz A, Slone J, Russell DH, Amrein H. The molecular basis of sugar sensing in Drosophila larvae. Curr Biol. 2013 Aug 5;23(15):1466-71. PMID:23850280 doi:10.1016/j.cub.2013.06.028

[7] Ma D, Hu M, Yang X, Liu Q, Ye F, Cai W, Wang Y, Xu X, Chang S, Wang R, Yang W, Ye S, Su N, Fan M, Xu H, Guo J. Structural basis for sugar perception by Drosophila gustatory receptors. Science. 2024 Feb 23;383(6685):eadj2609. PMID:38305684 doi:10.1126/science.adj2609

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