8xxl

Cryo-EM structure of the human 40S ribosome with PDCD4Cryo-EM structure of the human 40S ribosome with PDCD4

Structural highlights

8xxl is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.9Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RS32_HUMAN Component of the small ribosomal subunit (Probable) (Ref.8). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase II alpha by CKII (PubMed:9299532).^[1] ^[2] [REFERENCE:8]

References

↑ Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R. Structures of the human and Drosophila 80S ribosome. Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104. PMID:23636399 doi:10.1038/nature12104
↑ Lee JH, Kim JM, Kim MS, Lee YT, Marshak DR, Bae YS. The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII. Biochem Biophys Res Commun. 1997 Sep 18;238(2):462-7. PMID:9299532 doi:http://dx.doi.org/10.1006/bbrc.1997.7317

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OCA

[1] Anger AM, Armache JP, Berninghausen O, Habeck M, Subklewe M, Wilson DN, Beckmann R. Structures of the human and Drosophila 80S ribosome. Nature. 2013 May 2;497(7447):80-5. doi: 10.1038/nature12104. PMID:23636399 doi:10.1038/nature12104

[2] Lee JH, Kim JM, Kim MS, Lee YT, Marshak DR, Bae YS. The highly basic ribosomal protein L41 interacts with the beta subunit of protein kinase CKII and stimulates phosphorylation of DNA topoisomerase IIalpha by CKII. Biochem Biophys Res Commun. 1997 Sep 18;238(2):462-7. PMID:9299532 doi:http://dx.doi.org/10.1006/bbrc.1997.7317

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