8wo8

Crystal Structure of an RNA-binding protein, FAU-1, from Pyrococcus furiosusCrystal Structure of an RNA-binding protein, FAU-1, from Pyrococcus furiosus

Structural highlights

8wo8 is a 2 chain structure with sequence from Escherichia coli and Pyrococcus furiosus DSM 3638. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.78Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FAU1_PYRFU Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Preferentially cleaves UA sequences in the 5' precursor region of 5S rRNA (PubMed:28978920). Binds to RNA in loop regions with AU-rich sequences. Binds to the consensus sequence GGC(U/A)(U/A)U(U/C) in vitro (PubMed:12614195).^[1] ^[2]

References

↑ Kanai A, Oida H, Matsuura N, Doi H. Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus. Biochem J. 2003 May 15;372(Pt 1):253-61. PMID:12614195 doi:10.1042/BJ20021968
↑ Ikeda Y, Okada Y, Sato A, Kanai T, Tomita M, Atomi H, Kanai A. An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus. Sci Rep. 2017 Oct 4;7(1):12674. PMID:28978920 doi:10.1038/s41598-017-13062-3

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OCA

[1] Kanai A, Oida H, Matsuura N, Doi H. Expression cloning and characterization of a novel gene that encodes the RNA-binding protein FAU-1 from Pyrococcus furiosus. Biochem J. 2003 May 15;372(Pt 1):253-61. PMID:12614195 doi:10.1042/BJ20021968

[2] Ikeda Y, Okada Y, Sato A, Kanai T, Tomita M, Atomi H, Kanai A. An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus. Sci Rep. 2017 Oct 4;7(1):12674. PMID:28978920 doi:10.1038/s41598-017-13062-3

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