Crystal structure of human norovirus RNA-dependent RNA-polymeraseCrystal structure of human norovirus RNA-dependent RNA-polymerase

Structural highlights

8tuf is a 1 chain structure with sequence from Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.03Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

K4L8Z7_9CALI 3C-like protease processes the polyprotein: 3CLpro-RdRp is first released by autocleavage, then all other proteins are cleaved. May cleave polyadenylate-binding protein thereby inhibiting cellular translation.[PROSITE-ProRule:PRU00870]

8tuf, resolution 2.03Å

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OCA