8tk9

ZIG-4-INS-6 complex, tetragonal formZIG-4-INS-6 complex, tetragonal form

Structural highlights

8tk9 is a 2 chain structure with sequence from Caenorhabditis elegans. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.3Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ZIG4_CAEEL Required for maintaining axon position of PVQ and PVP neurons postembryonically in the ventral nerve cord (VNC) by preventing axons drifting into the opposite side of the VNC that could occur during body growth and movement.^[1] ^[2]

References

↑ Aurelio O, Hall DH, Hobert O. Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science. 2002 Jan 25;295(5555):686-90. PMID:11809975 doi:10.1126/science.1066642
↑ Bénard C, Tjoe N, Boulin T, Recio J, Hobert O. The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans. Genetics. 2009 Nov;183(3):917-27. PMID:19737747 doi:10.1534/genetics.109.107441

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OCA

[1] Aurelio O, Hall DH, Hobert O. Immunoglobulin-domain proteins required for maintenance of ventral nerve cord organization. Science. 2002 Jan 25;295(5555):686-90. PMID:11809975 doi:10.1126/science.1066642

[2] Bénard C, Tjoe N, Boulin T, Recio J, Hobert O. The small, secreted immunoglobulin protein ZIG-3 maintains axon position in Caenorhabditis elegans. Genetics. 2009 Nov;183(3):917-27. PMID:19737747 doi:10.1534/genetics.109.107441

[1]

[2]