8t2m

Crystal structure of GABARAP in complex with the LIR of NSs4Crystal structure of GABARAP in complex with the LIR of NSs4

Structural highlights

8t2m is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.27Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBRAP_HUMAN May play a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy (By similarity).^[1] NSS_RVFVZ Inhibits host general transcription by inhibiting host basal transcription factor TFIIH.^[2]

References

↑ Lee JH, Rho SB, Chun T. GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Biotechnol Lett. 2005 May;27(9):623-8. PMID:15977068 doi:http://dx.doi.org/10.1007/s10529-005-3628-2
↑ Kalveram B, Lihoradova O, Ikegami T. NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62. J Virol. 2011 Jul;85(13):6234-43. doi: 10.1128/JVI.02255-10. Epub 2011 May 4. PMID:21543505 doi:http://dx.doi.org/10.1128/JVI.02255-10

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OCA

[1] Lee JH, Rho SB, Chun T. GABAA receptor-associated protein (GABARAP) induces apoptosis by interacting with DEAD (Asp-Glu-Ala-Asp/His) box polypeptide 47 (DDX 47). Biotechnol Lett. 2005 May;27(9):623-8. PMID:15977068 doi:http://dx.doi.org/10.1007/s10529-005-3628-2

[2] Kalveram B, Lihoradova O, Ikegami T. NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62. J Virol. 2011 Jul;85(13):6234-43. doi: 10.1128/JVI.02255-10. Epub 2011 May 4. PMID:21543505 doi:http://dx.doi.org/10.1128/JVI.02255-10

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