8sp4

Crystal structure of N-terminally truncated Escherichia coli RapA in complex with ATP-gamma-SCrystal structure of N-terminally truncated Escherichia coli RapA in complex with ATP-gamma-S

Structural highlights

8sp4 is a 1 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.401Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAPA_ECOLI Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity).^[1]

References

↑ Sukhodolets MV, Cabrera JE, Zhi H, Jin DJ. RapA, a bacterial homolog of SWI2/SNF2, stimulates RNA polymerase recycling in transcription. Genes Dev. 2001 Dec 15;15(24):3330-41. PMID:11751638 doi:http://dx.doi.org/10.1101/gad.936701

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OCA

[1] Sukhodolets MV, Cabrera JE, Zhi H, Jin DJ. RapA, a bacterial homolog of SWI2/SNF2, stimulates RNA polymerase recycling in transcription. Genes Dev. 2001 Dec 15;15(24):3330-41. PMID:11751638 doi:http://dx.doi.org/10.1101/gad.936701

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