8skk

Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17

Structural highlights

8skk is a 2 chain structure with sequence from Amblyomma americanum and Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

E1243_AMBAM Salivary chemokine-binding protein which has chemokine-neutralizing activity and binds to host chemokines CCL1, CCL3, CCL3L1, CCL4, CCL4L1, CCL5, CCL7, CCL8, CCL13, CCL14, CCL15, CCL16, CCL17, CCL18, CCL19, CCL20, CCL21, CCL22, CCL23, CCL24, CCL27, XCL1, CX3CL1, CXCL1, CXCL2, CXCL4, CXCL5, CXCL6, CXCL7, CXCL9, CXCL12 and CXCL14.^[1]

References

↑ Alenazi Y, Singh K, Davies G, Eaton JRO, Elders P, Kawamura A, Bhattacharya S. Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Sci Rep. 2018 Apr 20;8(1):6333. PMID:29679010 doi:10.1038/s41598-018-24568-9

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OCA

[1] Alenazi Y, Singh K, Davies G, Eaton JRO, Elders P, Kawamura A, Bhattacharya S. Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Sci Rep. 2018 Apr 20;8(1):6333. PMID:29679010 doi:10.1038/s41598-018-24568-9

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