8qbv

Cryo-EM structure of Vipp1-deltaH6_aa1-219 helical filament with lattice 2 (Vipp1-deltaH6_L2)Cryo-EM structure of Vipp1-deltaH6_aa1-219 helical filament with lattice 2 (Vipp1-deltaH6_L2)

Structural highlights

8qbv is a 1 chain structure with sequence from Nostoc punctiforme. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.78Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

VIPP1_NOSP7 A membrane remodeling protein capable of forming rings and/or filaments on membranes, which then curve and tubulate the bilayer (Probable) (PubMed:34166615). Rings will form on liposomes, altering their positive curvature so the lipid bilayer is remodeled into a negative curve as the membrane enters the ring (PubMed:34166615). Ring stacks of varying lengths can be seen joining isolated liposomes (PubMed:34166615). A lipid monolayer can be drawn into the center of the rings (PubMed:34166615). Required for thylakoid formation (By similarity).[UniProtKB:Q55707]^[1] ^[2]

References

↑ Liu J, Tassinari M, Souza DP, Naskar S, Noel JK, Bohuszewicz O, Buck M, Williams TA, Baum B, Low HH. Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell. 2021 Jul 8;184(14):3660-3673.e18. doi: 10.1016/j.cell.2021.05.041. Epub, 2021 Jun 23. PMID:34166615 doi:http://dx.doi.org/10.1016/j.cell.2021.05.041
↑ Liu J, Tassinari M, Souza DP, Naskar S, Noel JK, Bohuszewicz O, Buck M, Williams TA, Baum B, Low HH. Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell. 2021 Jul 8;184(14):3660-3673.e18. doi: 10.1016/j.cell.2021.05.041. Epub, 2021 Jun 23. PMID:34166615 doi:http://dx.doi.org/10.1016/j.cell.2021.05.041

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Liu J, Tassinari M, Souza DP, Naskar S, Noel JK, Bohuszewicz O, Buck M, Williams TA, Baum B, Low HH. Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell. 2021 Jul 8;184(14):3660-3673.e18. doi: 10.1016/j.cell.2021.05.041. Epub, 2021 Jun 23. PMID:34166615 doi:http://dx.doi.org/10.1016/j.cell.2021.05.041

[2] Liu J, Tassinari M, Souza DP, Naskar S, Noel JK, Bohuszewicz O, Buck M, Williams TA, Baum B, Low HH. Bacterial Vipp1 and PspA are members of the ancient ESCRT-III membrane-remodeling superfamily. Cell. 2021 Jul 8;184(14):3660-3673.e18. doi: 10.1016/j.cell.2021.05.041. Epub, 2021 Jun 23. PMID:34166615 doi:http://dx.doi.org/10.1016/j.cell.2021.05.041

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