Structural highlightsFunctionSLN1_CANAL Histidine kinase involved in a two-component signaling pathway that regulates cell wall mannan biosynthesis. Part of the bifurcated SLN1-YPD1-SKN7/SSK1 two-component regulatory system, which controls activity of the HOG1 pathway and gene expression in response to oxidative stress and probably also to changes in the osmolarity of the extracellular environment. Plays a role in the regulation of alternative oxidase (AOX) gene family expression. Required for hyphal formation and virulence.[1] [2] [3] [4] [5]
References
- ↑ Yamada-Okabe T, Mio T, Ono N, Kashima Y, Matsui M, Arisawa M, Yamada-Okabe H. Roles of three histidine kinase genes in hyphal development and virulence of the pathogenic fungus Candida albicans. J Bacteriol. 1999 Dec;181(23):7243-7. PMID:10572127 doi:10.1128/JB.181.23.7243-7247.1999
- ↑ Huh WK, Kang SO. Characterization of the gene family encoding alternative oxidase from Candida albicans. Biochem J. 2001 Jun 1;356(Pt 2):595-604. PMID:11368790 doi:10.1042/0264-6021:3560595
- ↑ Kruppa M, Jabra-Rizk MA, Meiller TF, Calderone R. The histidine kinases of Candida albicans: regulation of cell wall mannan biosynthesis. FEMS Yeast Res. 2004 Jan;4(4-5):409-16. PMID:14734021 doi:10.1016/S1567-1356(03)00201-0
- ↑ Menon V, Li D, Chauhan N, Rajnarayanan R, Dubrovska A, West AH, Calderone R. Functional studies of the Ssk1p response regulator protein of Candida albicans as determined by phenotypic analysis of receiver domain point mutants. Mol Microbiol. 2006 Nov;62(4):997-1013. PMID:17038117 doi:10.1111/j.1365-2958.2006.05438.x
- ↑ Nagahashi S, Mio T, Ono N, Yamada-Okabe T, Arisawa M, Bussey H, Yamada-Okabe H. Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans. Microbiology (Reading). 1998 Feb;144 ( Pt 2):425-432. PMID:9493379 doi:10.1099/00221287-144-2-425
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