8jda

Cyro-EM structure of the Na+/H+ antipoter SOS1 from Arabidopsis thaliana,class2Cyro-EM structure of the Na+/H+ antipoter SOS1 from Arabidopsis thaliana,class2

Structural highlights

8jda is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.67Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NHX7_ARATH Acts in electroneutral exchange of protons for cations such as Na(+) or Li(+) across plasma membrane. Involved in Na(+) and K(+) homeostasis. Required for cytoplasmic Na(+) and Li(+) detoxification by secreting them from the cytoplasm to the extracellular space. Regulates Na(+) content of the xylem sap.^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Shi H, Ishitani M, Kim C, Zhu JK. The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6896-901. PMID:10823923 doi:10.1073/pnas.120170197
↑ Shi H, Quintero FJ, Pardo JM, Zhu JK. The putative plasma membrane Na(+)/H(+) antiporter SOS1 controls long-distance Na(+) transport in plants. Plant Cell. 2002 Feb;14(2):465-77. PMID:11884687 doi:10.1105/tpc.010371
↑ Qiu QS, Guo Y, Dietrich MA, Schumaker KS, Zhu JK. Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8436-41. Epub 2002 May 28. PMID:12034882 doi:http://dx.doi.org/10.1073/pnas.122224699
↑ Wu SJ, Ding L, Zhu JK. SOS1, a Genetic Locus Essential for Salt Tolerance and Potassium Acquisition. Plant Cell. 1996 Apr;8(4):617-627. PMID:12239394 doi:10.1105/tpc.8.4.617
↑ Shi H, Lee BH, Wu SJ, Zhu JK. Overexpression of a plasma membrane Na+/H+ antiporter gene improves salt tolerance in Arabidopsis thaliana. Nat Biotechnol. 2003 Jan;21(1):81-5. PMID:12469134 doi:10.1038/nbt766
↑ Qiu QS, Barkla BJ, Vera-Estrella R, Zhu JK, Schumaker KS. Na+/H+ exchange activity in the plasma membrane of Arabidopsis. Plant Physiol. 2003 Jun;132(2):1041-52. PMID:12805632 doi:10.1104/pp.102.010421

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OCA

[1] Shi H, Ishitani M, Kim C, Zhu JK. The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6896-901. PMID:10823923 doi:10.1073/pnas.120170197

[2] Shi H, Quintero FJ, Pardo JM, Zhu JK. The putative plasma membrane Na(+)/H(+) antiporter SOS1 controls long-distance Na(+) transport in plants. Plant Cell. 2002 Feb;14(2):465-77. PMID:11884687 doi:10.1105/tpc.010371

[3] Qiu QS, Guo Y, Dietrich MA, Schumaker KS, Zhu JK. Regulation of SOS1, a plasma membrane Na+/H+ exchanger in Arabidopsis thaliana, by SOS2 and SOS3. Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8436-41. Epub 2002 May 28. PMID:12034882 doi:http://dx.doi.org/10.1073/pnas.122224699

[4] Wu SJ, Ding L, Zhu JK. SOS1, a Genetic Locus Essential for Salt Tolerance and Potassium Acquisition. Plant Cell. 1996 Apr;8(4):617-627. PMID:12239394 doi:10.1105/tpc.8.4.617

[5] Shi H, Lee BH, Wu SJ, Zhu JK. Overexpression of a plasma membrane Na+/H+ antiporter gene improves salt tolerance in Arabidopsis thaliana. Nat Biotechnol. 2003 Jan;21(1):81-5. PMID:12469134 doi:10.1038/nbt766

[6] Qiu QS, Barkla BJ, Vera-Estrella R, Zhu JK, Schumaker KS. Na+/H+ exchange activity in the plasma membrane of Arabidopsis. Plant Physiol. 2003 Jun;132(2):1041-52. PMID:12805632 doi:10.1104/pp.102.010421

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