8ip4

Cryo-EM structure of hMRS-highEDTACryo-EM structure of hMRS-highEDTA

Structural highlights

8ip4 is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 2.7Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

MRS2_HUMAN Magnesium transporter that mediates the influx of magnesium into the mitochondrial matrix (PubMed:11401429, PubMed:18384665). Required for normal expression of the mitochondrial respiratory complex I subunits (PubMed:18384665).^[1] ^[2]

References

↑ Zsurka G, Gregán J, Schweyen RJ. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics. 2001 Mar 1;72(2):158-68. PMID:11401429 doi:10.1006/geno.2000.6407
↑ Piskacek M, Zotova L, Zsurka G, Schweyen RJ. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. J Cell Mol Med. 2009 Apr;13(4):693-700. PMID:18384665 doi:10.1111/j.1582-4934.2008.00328.x

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OCA

[1] Zsurka G, Gregán J, Schweyen RJ. The human mitochondrial Mrs2 protein functionally substitutes for its yeast homologue, a candidate magnesium transporter. Genomics. 2001 Mar 1;72(2):158-68. PMID:11401429 doi:10.1006/geno.2000.6407

[2] Piskacek M, Zotova L, Zsurka G, Schweyen RJ. Conditional knockdown of hMRS2 results in loss of mitochondrial Mg(2+) uptake and cell death. J Cell Mol Med. 2009 Apr;13(4):693-700. PMID:18384665 doi:10.1111/j.1582-4934.2008.00328.x

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