8gp6

Structure of the vaccinia virus A16/G9 sub-complex from the orthopoxvirus entry-fusion complexStructure of the vaccinia virus A16/G9 sub-complex from the orthopoxvirus entry-fusion complex

Structural highlights

8gp6 is a 2 chain structure with sequence from Vaccinia virus WR. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.7Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PG094_VACCW Component of the entry fusion complex (EFC), which consists of 11 proteins. During cell infection, this complex mediates entry of the virion core into the host cytoplasm by a two-step mechanism consisting of lipid mixing of the viral and cellular membranes and subsequent pore formation.^[1] ^[2] ^[3]

References

↑ Senkevich TG, Ojeda S, Townsley A, Nelson GE, Moss B. Poxvirus multiprotein entry-fusion complex. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18572-7. PMID:16339313 doi:10.1073/pnas.0509239102
↑ Ojeda S, Domi A, Moss B. Vaccinia virus G9 protein is an essential component of the poxvirus entry-fusion complex. J Virol. 2006 Oct;80(19):9822-30. PMID:16973586 doi:10.1128/JVI.00987-06
↑ Schin AM, Diesterbeck US, Moss B. Insights into the Organization of the Poxvirus Multicomponent Entry-Fusion Complex from Proximity Analyses in Living Infected Cells. J Virol. 2021 Jul 26;95(16):e0085221. PMID:34076488 doi:10.1128/JVI.00852-21

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OCA

[1] Senkevich TG, Ojeda S, Townsley A, Nelson GE, Moss B. Poxvirus multiprotein entry-fusion complex. Proc Natl Acad Sci U S A. 2005 Dec 20;102(51):18572-7. PMID:16339313 doi:10.1073/pnas.0509239102

[2] Ojeda S, Domi A, Moss B. Vaccinia virus G9 protein is an essential component of the poxvirus entry-fusion complex. J Virol. 2006 Oct;80(19):9822-30. PMID:16973586 doi:10.1128/JVI.00987-06

[3] Schin AM, Diesterbeck US, Moss B. Insights into the Organization of the Poxvirus Multicomponent Entry-Fusion Complex from Proximity Analyses in Living Infected Cells. J Virol. 2021 Jul 26;95(16):e0085221. PMID:34076488 doi:10.1128/JVI.00852-21

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