8f8k

The structure of Rv2173 from M. tuberculosis with IPP boundThe structure of Rv2173 from M. tuberculosis with IPP bound

Structural highlights

8f8k is a 1 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.2Å
Ligands:	, , , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GFPPS_MYCTU Catalyzes the sequential condensations of isopentenyl pyrophosphate (IPP) with dimethylallyl diphosphate (DMAPP) to yield geranyl diphosphate (GPP) and with GPP to yield (2E,6E)-farnesyl diphosphate (E,E-FPP).^[1]

References

↑ Abe T, Ozaki S, Ueda D, Sato T. Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis. Chembiochem. 2020 Oct 15;21(20):2931-2938. PMID:32495977 doi:10.1002/cbic.202000235

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OCA

[1] Abe T, Ozaki S, Ueda D, Sato T. Insight into Isoprenoid Biosynthesis by Functional Analysis of Isoprenyl Diphosphate Synthases from Mycobacterium vanbaalenii and Mycobacterium tuberculosis. Chembiochem. 2020 Oct 15;21(20):2931-2938. PMID:32495977 doi:10.1002/cbic.202000235

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