Proteopedia

8ebm

Structure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimicStructure of KLHDC2 substrate binding domain bound to KLHDC2's C-degron mimic

Structural highlights

8ebm is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.58Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KLDC2_HUMAN Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.[1]

References

  1. ↑ Zhou HJ, Wong CM, Chen JH, Qiang BQ, Yuan JG, Jin DY. Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein. J Biol Chem. 2001 Aug 3;276(31):28933-8. doi: 10.1074/jbc.M103893200. Epub 2001, May 30. PMID:11384994 doi:http://dx.doi.org/10.1074/jbc.M103893200

8ebm, resolution 1.58Å

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OCA
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