8dzn

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Crystal structure of human Sar1a in complex with GDPCrystal structure of human Sar1a in complex with GDP

Structural highlights

8dzn is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.107Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SAR1A_HUMAN Involved in transport from the endoplasmic reticulum to the Golgi apparatus (By similarity). Required to maintain SEC16A localization at discrete locations on the ER membrane perhaps by preventing its dissociation. SAR1A-GTP-dependent assembly of SEC16A on the ER membrane forms an organized scaffold defining endoplasmic reticulum exit sites (ERES).[1]

References

  1. Watson P, Townley AK, Koka P, Palmer KJ, Stephens DJ. Sec16 defines endoplasmic reticulum exit sites and is required for secretory cargo export in mammalian cells. Traffic. 2006 Dec;7(12):1678-87. Epub 2006 Sep 27. PMID:17005010 doi:http://dx.doi.org/10.1111/j.1600-0854.2006.00493.x

8dzn, resolution 2.11Å

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OCA