7zpr

KtrAB complex with N-terminal deletion of KtrB 1-19KtrAB complex with N-terminal deletion of KtrB 1-19

Structural highlights

7zpr is a 12 chain structure with sequence from Vibrio alginolyticus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.56Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KTRA_VIBAL Part of the Na(+)-dependent high affinity K(+) uptake system KtrAB. KtrA is the regulatory subunit and plays an important role in the substrate specificity and transport mechanism of the system. Binds ATP but lacks ATPase activity.^[1] ^[2] ^[3]

References

↑ Tholema N, Vor der Brüggen M, Mäser P, Nakamura T, Schroeder JI, Kobayashi H, Uozumi N, Bakker EP. All four putative selectivity filter glycine residues in KtrB are essential for high affinity and selective K+ uptake by the KtrAB system from Vibrio alginolyticus. J Biol Chem. 2005 Dec 16;280(50):41146-54. PMID:16210320 doi:10.1074/jbc.M507647200
↑ Kröning N, Willenborg M, Tholema N, Hänelt I, Schmid R, Bakker EP. ATP binding to the KTN/RCK subunit KtrA from the K+ -uptake system KtrAB of Vibrio alginolyticus: its role in the formation of the KtrAB complex and its requirement in vivo. J Biol Chem. 2007 May 11;282(19):14018-27. PMID:17344221 doi:10.1074/jbc.M609084200
↑ Nakamura T, Yuda R, Unemoto T, Bakker EP. KtrAB, a new type of bacterial K(+)-uptake system from Vibrio alginolyticus. J Bacteriol. 1998 Jul;180(13):3491-4. PMID:9642210 doi:10.1128/JB.180.13.3491-3494.1998

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OCA

[1] Tholema N, Vor der Brüggen M, Mäser P, Nakamura T, Schroeder JI, Kobayashi H, Uozumi N, Bakker EP. All four putative selectivity filter glycine residues in KtrB are essential for high affinity and selective K+ uptake by the KtrAB system from Vibrio alginolyticus. J Biol Chem. 2005 Dec 16;280(50):41146-54. PMID:16210320 doi:10.1074/jbc.M507647200

[2] Kröning N, Willenborg M, Tholema N, Hänelt I, Schmid R, Bakker EP. ATP binding to the KTN/RCK subunit KtrA from the K+ -uptake system KtrAB of Vibrio alginolyticus: its role in the formation of the KtrAB complex and its requirement in vivo. J Biol Chem. 2007 May 11;282(19):14018-27. PMID:17344221 doi:10.1074/jbc.M609084200

[3] Nakamura T, Yuda R, Unemoto T, Bakker EP. KtrAB, a new type of bacterial K(+)-uptake system from Vibrio alginolyticus. J Bacteriol. 1998 Jul;180(13):3491-4. PMID:9642210 doi:10.1128/JB.180.13.3491-3494.1998

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