7yqa

Crystal structure of D-threonine aldolase from Chlamydomonas reinhardtiiCrystal structure of D-threonine aldolase from Chlamydomonas reinhardtii

Structural highlights 7yqa is a 4 chain structure with sequence from Chlamydomonas reinhardtii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.85Å Ligands: , Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function A0A1C9ZZ39_CHLRE Publication Abstract from PubMed D-Threonine aldolase (DTA) is a pyridoxal-5'-phosphate-dependent enzyme which catalyzes the reversible aldol reaction of glycine with a corresponding aldehyde to yield the D-form beta-hydroxy-alpha-amino acid. This study produced and investigated the crystal structure of DTA from Chlamydomonas reinhardtii (CrDTA) at 1.85 A resolution. To our knowledge, this is the first report on the crystal structure of eukaryotic DTA. Compared with the structure of bacterial DTA, CrDTA has a similar arrangement of active-site residues. On the other hand, we speculated that some non-conserved residues alter the affinity for substrates and inhibitors. The structure of CrDTA could provide insights into the structural framework for structure-guided protein engineering studies to modify reaction selectivity. Structure of pyridoxal 5'-phosphate-bound D-threonine aldolase from Chlamydomonas reinhardtii.,Hirato Y, Goto M, Mizobuchi T, Muramatsu H, Tanigawa M, Nishimura K Acta Crystallogr F Struct Biol Commun. 2023 Feb 1;79(Pt 2):31-37. doi: , 10.1107/S2053230X23000304. Epub 2023 Feb 2. PMID:36748339 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 7yqa, resolution 1.85Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image