7wl2

Mouse Pendrin in bicarbonate and iodide buffer in inward stateMouse Pendrin in bicarbonate and iodide buffer in inward state

Structural highlights

7wl2 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.25Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

S26A4_MOUSE Sodium-independent transporter of chloride and iodide (By similarity). Mediates electroneutral iodide-chloride, iodide-bicarbonate and chloride-bicarbonate exchange with 1:1 stoichiometry (PubMed:11274445, PubMed:18565999). Mediates elctroneutral chloride-formate exchange (By similarity).[UniProtKB:Q9R154]^[1] ^[2]

References

↑ Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED. Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4221-6. PMID:11274445 doi:10.1073/pnas.071516798
↑ Shcheynikov N, Yang D, Wang Y, Zeng W, Karniski LP, So I, Wall SM, Muallem S. The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3 J Physiol. 2008 Aug 15;586(16):3813-24. PMID:18565999 doi:10.1113/jphysiol.2008.154468

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OCA

[1] Royaux IE, Wall SM, Karniski LP, Everett LA, Suzuki K, Knepper MA, Green ED. Pendrin, encoded by the Pendred syndrome gene, resides in the apical region of renal intercalated cells and mediates bicarbonate secretion. Proc Natl Acad Sci U S A. 2001 Mar 27;98(7):4221-6. PMID:11274445 doi:10.1073/pnas.071516798

[2] Shcheynikov N, Yang D, Wang Y, Zeng W, Karniski LP, So I, Wall SM, Muallem S. The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3 J Physiol. 2008 Aug 15;586(16):3813-24. PMID:18565999 doi:10.1113/jphysiol.2008.154468

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