7ulr

recombinant kappa-bungarotoxinrecombinant kappa-bungarotoxin

Structural highlights

7ulr is a 2 chain structure with sequence from Bungarus multicinctus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

3LKB_BUNMU Postsynaptic neurotoxin that binds and inhibits neuronal nicotinic acetylcholine receptors (nAChR) with high affinity (IC(50)<100 nM). Is a selective, and slowly reversible antagonist of alpha-3/CHRNA3-containing and some alpha-4/CHRNA4-containing AChRs.^[1] ^[2]

References

↑ Grant GA, Chiappinelli VA. kappa-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe. Biochemistry. 1985 Mar 12;24(6):1532-7. PMID:3986193
↑ Chiappinelli VA, Weaver WR, McLane KE, Conti-Fine BM, Fiordalisi JJ, Grant GA. Binding of native kappa-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors. Toxicon. 1996 Nov-Dec;34(11-12):1243-56. PMID:9027980 doi:10.1016/s0041-0101(96)00110-9

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OCA

[1] Grant GA, Chiappinelli VA. kappa-Bungarotoxin: complete amino acid sequence of a neuronal nicotinic receptor probe. Biochemistry. 1985 Mar 12;24(6):1532-7. PMID:3986193

[2] Chiappinelli VA, Weaver WR, McLane KE, Conti-Fine BM, Fiordalisi JJ, Grant GA. Binding of native kappa-neurotoxins and site-directed mutants to nicotinic acetylcholine receptors. Toxicon. 1996 Nov-Dec;34(11-12):1243-56. PMID:9027980 doi:10.1016/s0041-0101(96)00110-9

[1]

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