7u9e

Pfs230 D1 domain in complex with 230AL-26Pfs230 D1 domain in complex with 230AL-26

Structural highlights

7u9e is a 3 chain structure with sequence from Homo sapiens and Plasmodium falciparum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.39Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

P230_PLAF7 Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with erythrocytes.^[1]

References

↑ Eksi S, Czesny B, van Gemert GJ, Sauerwein RW, Eling W, Williamson KC. Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production. Mol Microbiol. 2006 Aug;61(4):991-8. doi: 10.1111/j.1365-2958.2006.05284.x. PMID:16879650 doi:http://dx.doi.org/10.1111/j.1365-2958.2006.05284.x

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OCA

[1] Eksi S, Czesny B, van Gemert GJ, Sauerwein RW, Eling W, Williamson KC. Malaria transmission-blocking antigen, Pfs230, mediates human red blood cell binding to exflagellating male parasites and oocyst production. Mol Microbiol. 2006 Aug;61(4):991-8. doi: 10.1111/j.1365-2958.2006.05284.x. PMID:16879650 doi:http://dx.doi.org/10.1111/j.1365-2958.2006.05284.x

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