7rk4

Mannitol-2-dehydrogenase from Aspergillus fumigatusMannitol-2-dehydrogenase from Aspergillus fumigatus

Structural highlights

7rk4 is a 2 chain structure with sequence from Aspergillus fumigatus Af293. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

M2DH_ASPFU Catalyzes the NAD(H)-dependent interconversion of D-fructose and D-mannitol in the mannitol metabolic pathway. Has a preference for NADH over NADPH.^[1]

References

↑ Krahulec S, Armao GC, Bubner P, Klimacek M, Nidetzky B. Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase. Chem Biol Interact. 2009 Mar 16;178(1-3):274-82. doi: 10.1016/j.cbi.2008.10.001. , Epub 2008 Oct 15. PMID:18983992 doi:http://dx.doi.org/10.1016/j.cbi.2008.10.001

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OCA

[1] Krahulec S, Armao GC, Bubner P, Klimacek M, Nidetzky B. Polyol-specific long-chain dehydrogenases/reductases of mannitol metabolism in Aspergillus fumigatus: biochemical characterization and pH studies of mannitol 2-dehydrogenase and mannitol-1-phosphate 5-dehydrogenase. Chem Biol Interact. 2009 Mar 16;178(1-3):274-82. doi: 10.1016/j.cbi.2008.10.001. , Epub 2008 Oct 15. PMID:18983992 doi:http://dx.doi.org/10.1016/j.cbi.2008.10.001

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