Complex of O-acety-L-homoserine aminocarboxypropyltransferase (MetY) from Thermotoga maritima and a key reaction intermediateComplex of O-acety-L-homoserine aminocarboxypropyltransferase (MetY) from Thermotoga maritima and a key reaction intermediate

Structural highlights

7kb1 is a 4 chain structure with sequence from Thermotoga maritima MSB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.85Å
Ligands:, , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

METY_THEMA Catalyzes the production of homocysteine from O-acetylhomoserine (OAH) and hydrogen sulfide (H2S), a step in the methionine biosynthesis pathway. Is not able to form cystathionine from O-acetylhomoserine and L-cysteine.[1]

References

  1. Ferla MP, Brewster JL, Hall KR, Evans GB, Patrick WM. Primordial-like enzymes from bacteria with reduced genomes. Mol Microbiol. 2017 Aug;105(4):508-524. doi: 10.1111/mmi.13737. Epub 2017 Jul 6. PMID:28640457 doi:http://dx.doi.org/10.1111/mmi.13737

7kb1, resolution 1.85Å

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