7jk3

Structure of Drosophila ORC bound to GC-rich DNA and Cdc6Structure of Drosophila ORC bound to GC-rich DNA and Cdc6

Structural highlights

7jk3 is a 9 chain structure with sequence from Drosophila melanogaster and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.4Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ORC2_DROME Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.^[1]

References

↑ Loupart ML, Krause SA, Heck MS. Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants. Curr Biol. 2000 Dec 14-28;10(24):1547-56. PMID:11137005

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OCA

[1] Loupart ML, Krause SA, Heck MS. Aberrant replication timing induces defective chromosome condensation in Drosophila ORC2 mutants. Curr Biol. 2000 Dec 14-28;10(24):1547-56. PMID:11137005

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