7fdl

Crystal structure of transcription factor WER in complex with EGL3Crystal structure of transcription factor WER in complex with EGL3

Structural highlights

7fdl is a 12 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.897Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

EGL1_ARATH Transcription activator, when associated with MYB75/PAP1, MYB90/PAP2 or TT2. Involved in epidermal cell fate specification. Regulates negatively stomata formation but promotes trichome formation. Together with MYB66/WER, promotes the formation of non-hair cells in root epidermis cells in the N position. Whereas together with CPC, promotes the formation of hair cells in root epidermis cells in the H position by inhibiting non-hair cell formation. Seems also to play a role in the activation of anthocyanin biosynthesis, probably together with MYB75/PAP1. Involved in seed mucilage production. Activates the transcription of GL2.^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Zhang F, Gonzalez A, Zhao M, Payne CT, Lloyd A. A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis. Development. 2003 Oct;130(20):4859-69. Epub 2003 Aug 13. PMID:12917293 doi:http://dx.doi.org/10.1242/dev.00681
↑ Ramsay NA, Walker AR, Mooney M, Gray JC. Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Plant Mol Biol. 2003 Jun;52(3):679-88. doi: 10.1023/a:1024852021124. PMID:12956536 doi:http://dx.doi.org/10.1023/a:1024852021124
↑ Bernhardt C, Lee MM, Gonzalez A, Zhang F, Lloyd A, Schiefelbein J. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development. 2003 Dec;130(26):6431-9. Epub 2003 Nov 19. PMID:14627722 doi:http://dx.doi.org/10.1242/dev.00880
↑ Zimmermann IM, Heim MA, Weisshaar B, Uhrig JF. Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J. 2004 Oct;40(1):22-34. doi: 10.1111/j.1365-313X.2004.02183.x. PMID:15361138 doi:http://dx.doi.org/10.1111/j.1365-313X.2004.02183.x
↑ Bernhardt C, Zhao M, Gonzalez A, Lloyd A, Schiefelbein J. The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis. Development. 2005 Jan;132(2):291-8. Epub 2004 Dec 8. PMID:15590742 doi:http://dx.doi.org/dev.01565

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OCA

[1] Zhang F, Gonzalez A, Zhao M, Payne CT, Lloyd A. A network of redundant bHLH proteins functions in all TTG1-dependent pathways of Arabidopsis. Development. 2003 Oct;130(20):4859-69. Epub 2003 Aug 13. PMID:12917293 doi:http://dx.doi.org/10.1242/dev.00681

[2] Ramsay NA, Walker AR, Mooney M, Gray JC. Two basic-helix-loop-helix genes (MYC-146 and GL3) from Arabidopsis can activate anthocyanin biosynthesis in a white-flowered Matthiola incana mutant. Plant Mol Biol. 2003 Jun;52(3):679-88. doi: 10.1023/a:1024852021124. PMID:12956536 doi:http://dx.doi.org/10.1023/a:1024852021124

[3] Bernhardt C, Lee MM, Gonzalez A, Zhang F, Lloyd A, Schiefelbein J. The bHLH genes GLABRA3 (GL3) and ENHANCER OF GLABRA3 (EGL3) specify epidermal cell fate in the Arabidopsis root. Development. 2003 Dec;130(26):6431-9. Epub 2003 Nov 19. PMID:14627722 doi:http://dx.doi.org/10.1242/dev.00880

[4] Zimmermann IM, Heim MA, Weisshaar B, Uhrig JF. Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins. Plant J. 2004 Oct;40(1):22-34. doi: 10.1111/j.1365-313X.2004.02183.x. PMID:15361138 doi:http://dx.doi.org/10.1111/j.1365-313X.2004.02183.x

[5] Bernhardt C, Zhao M, Gonzalez A, Lloyd A, Schiefelbein J. The bHLH genes GL3 and EGL3 participate in an intercellular regulatory circuit that controls cell patterning in the Arabidopsis root epidermis. Development. 2005 Jan;132(2):291-8. Epub 2004 Dec 8. PMID:15590742 doi:http://dx.doi.org/dev.01565

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