7dyb

Thermotoga maritima ferritin mutant-FLAL-LThermotoga maritima ferritin mutant-FLAL-L

Structural highlights 7dyb is a 3 chain structure with sequence from Thermotoga maritima MSB8. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: X-ray diffraction, Resolution 1.779Å Ligands: Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function Q9X0L2_THEMA Iron storage protein (By similarity).[RuleBase:RU361145] Publication Abstract from PubMed Although various artificial protein nanoarchitectures have been constructed, controlling the transformation between different protein assemblies has largely been unexplored. Here, we describe an approach to realize the self-assembly transformation of dimeric building blocks by adjusting their geometric arrangement. Thermotoga maritima ferritin (TmFtn) naturally occurs as a dimer; twelve of these dimers interact with each other in a head-to-side manner to generate 24-meric hollow protein nanocage in the presence of Ca(2+) or PEG. By tuning two contiguous dimeric proteins to interact in a fully or partially side-by-side fashion through protein interface redesign, we can render the self-assembly transformation of such dimeric building blocks from the protein nanocage to filament, nanorod and nanoribbon in response to multiple external stimuli. We show similar dimeric protein building blocks can generate three kinds of protein materials in a manner that highly resembles natural pentamer building blocks from viral capsids that form different protein assemblies. Protein interface redesign facilitates the transformation of nanocage building blocks to 1D and 2D nanomaterials.,Zhang X, Liu Y, Zheng B, Zang J, Lv C, Zhang T, Wang H, Zhao G Nat Commun. 2021 Aug 11;12(1):4849. doi: 10.1038/s41467-021-25199-x. PMID:34381032 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ferritin 3D structures

spinqualitylabelsall models 7dyb, resolution 1.78Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image