7dow

The structure of the Arabidopsis thaliana guanosine deaminase in reaction with 7-deazaguansoineThe structure of the Arabidopsis thaliana guanosine deaminase in reaction with 7-deazaguansoine

Structural highlights

7dow is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GSDA_ARATH Catalyzes the hydrolytic deamination of guanosine, producing xanthosine and ammonia. Deaminates exclusively guanosine and 2'-deoxyguanosine but no other aminated purines, pyrimidines, or pterines. Deamination of guanosine by GSDA is the only source of xanthosine production in Arabidopsis.^[1]

References

↑ Dahncke K, Witte CP. Plant purine nucleoside catabolism employs a guanosine deaminase required for the generation of xanthosine in Arabidopsis. Plant Cell. 2013 Oct;25(10):4101-9. doi: 10.1105/tpc.113.117184. Epub 2013 Oct, 15. PMID:24130159 doi:http://dx.doi.org/10.1105/tpc.113.117184

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OCA

[1] Dahncke K, Witte CP. Plant purine nucleoside catabolism employs a guanosine deaminase required for the generation of xanthosine in Arabidopsis. Plant Cell. 2013 Oct;25(10):4101-9. doi: 10.1105/tpc.113.117184. Epub 2013 Oct, 15. PMID:24130159 doi:http://dx.doi.org/10.1105/tpc.113.117184

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