7cvv

Crystal structure of Catechol o-methyl transferase (COMT) from Niastella koreensisCrystal structure of Catechol o-methyl transferase (COMT) from Niastella koreensis

Structural highlights

7cvv is a 3 chain structure with sequence from Niastella koreensis GR20-10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.52Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CAMT_NIAKG Catechol O-methyltransferase that can use various catechol-like compounds (PubMed:33596655). Can produce vanillic acid (meta-form) and iso-vanillic acid (para-form) from protocatechuic acid (PCA) (PubMed:33596655). Does not have a regiospecificity, and produces the meta- and para-forms of the products in equal proportion (PubMed:33596655).^[1]

References

↑ Lee SH, Kim B, Kim KJ. Crystal Structure and Regiospecificity of Catechol O-Methyltransferase from Niastella koreensis. J Agric Food Chem. 2021 Mar 3;69(8):2531-2538. PMID:33596655 doi:10.1021/acs.jafc.0c07621

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OCA

[1] Lee SH, Kim B, Kim KJ. Crystal Structure and Regiospecificity of Catechol O-Methyltransferase from Niastella koreensis. J Agric Food Chem. 2021 Mar 3;69(8):2531-2538. PMID:33596655 doi:10.1021/acs.jafc.0c07621

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