7ctx

Crystal structure of Arabidopsis thaliana SOBIR1 kinase domain(residues 388-401 deleted) in complex with AMP-PNP and magnesiumCrystal structure of Arabidopsis thaliana SOBIR1 kinase domain(residues 388-401 deleted) in complex with AMP-PNP and magnesium

Structural highlights

7ctx is a 2 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.907Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SBIR1_ARATH Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Acting as a counterplayer of BIR1, promotes the activation of plant defense and cell death (PubMed:19616764). Component of the RLP23-SOBIR1-BAK1 complex that mediates NLP-triggered immunity (PubMed:27251392). Functions as an inhibitor/regulator of abscission, probably by regulating membrane trafficking during abscission (PubMed:20081191).^[1] ^[2] ^[3]

References

↑ Gao M, Wang X, Wang D, Xu F, Ding X, Zhang Z, Bi D, Cheng YT, Chen S, Li X, Zhang Y. Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe. 2009 Jul 23;6(1):34-44. doi: 10.1016/j.chom.2009.05.019. PMID:19616764 doi:http://dx.doi.org/10.1016/j.chom.2009.05.019
↑ Leslie ME, Lewis MW, Youn JY, Daniels MJ, Liljegren SJ. The EVERSHED receptor-like kinase modulates floral organ shedding in Arabidopsis. Development. 2010 Feb;137(3):467-76. doi: 10.1242/dev.041335. PMID:20081191 doi:http://dx.doi.org/10.1242/dev.041335
↑ Albert I, Bohm H, Albert M, Feiler CE, Imkampe J, Wallmeroth N, Brancato C, Raaymakers TM, Oome S, Zhang H, Krol E, Grefen C, Gust AA, Chai J, Hedrich R, Van den Ackerveken G, Nurnberger T. An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nat Plants. 2015 Oct 5;1:15140. doi: 10.1038/nplants.2015.140. PMID:27251392 doi:http://dx.doi.org/10.1038/nplants.2015.140

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OCA

[1] Gao M, Wang X, Wang D, Xu F, Ding X, Zhang Z, Bi D, Cheng YT, Chen S, Li X, Zhang Y. Regulation of cell death and innate immunity by two receptor-like kinases in Arabidopsis. Cell Host Microbe. 2009 Jul 23;6(1):34-44. doi: 10.1016/j.chom.2009.05.019. PMID:19616764 doi:http://dx.doi.org/10.1016/j.chom.2009.05.019

[2] Leslie ME, Lewis MW, Youn JY, Daniels MJ, Liljegren SJ. The EVERSHED receptor-like kinase modulates floral organ shedding in Arabidopsis. Development. 2010 Feb;137(3):467-76. doi: 10.1242/dev.041335. PMID:20081191 doi:http://dx.doi.org/10.1242/dev.041335

[3] Albert I, Bohm H, Albert M, Feiler CE, Imkampe J, Wallmeroth N, Brancato C, Raaymakers TM, Oome S, Zhang H, Krol E, Grefen C, Gust AA, Chai J, Hedrich R, Van den Ackerveken G, Nurnberger T. An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity. Nat Plants. 2015 Oct 5;1:15140. doi: 10.1038/nplants.2015.140. PMID:27251392 doi:http://dx.doi.org/10.1038/nplants.2015.140

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