7c4u
MicroED structure of orthorhombic Vancomycin at 1.2 A resolutionMicroED structure of orthorhombic Vancomycin at 1.2 A resolution
Structural highlights
Publication Abstract from PubMedIt has been long-pursued but remains a challenge to precisely manipulate the molecular assembly process to obtain desired functional structures. Reported here is the control over the assembly of solute molecules, by a programmed recrystallization of solvent crystal grains, to form micro/nanoparticles with tunable sizes and crystalline forms. A quantitative correlation between the protocol of recrystallization temperature and the assembly kinetics results in precise control over the size of assembled particles, ranging from single-atom catalysts, pure drug nanoparticles, to sub-millimeter organic-semiconductor single crystals. The extensive regulation of the assembly rates leads to the unique and powerful capability of tuning the stacking of molecules, involving the formation of single crystals of notoriously crystallization-resistant molecules and amorphous structures of molecules with a very high propensity to crystallize, which endows it with wide-ranging applications. Precise Control Over Kinetics of Molecular Assembly: Production of Particles with Tunable Sizes and Crystalline Forms.,Fan Q, Li L, Xue H, Zhou H, Zhao L, Liu J, Mao J, Wu S, Zhang S, Wu C, Li X, Zhou X, Wang J Angew Chem Int Ed Engl. 2020 May 20. doi: 10.1002/anie.202003922. PMID:32432368[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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