Proteopedia

7bp6

Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)

Structural highlights

7bp6 is a 3 chain structure with sequence from Arabidopsis thaliana. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.58Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

H2A6_ARATH Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for the T-DNA integration step of plant transformation by Agrobacterium. May play an important role in illegitimate recombination.[1] [2]

References

  1. ↑ Mysore KS, Nam J, Gelvin SB. An Arabidopsis histone H2A mutant is deficient in Agrobacterium T-DNA integration. Proc Natl Acad Sci U S A. 2000 Jan 18;97(2):948-53. PMID:10639185 doi:10.1073/pnas.97.2.948
  2. ↑ Yi H, Mysore KS, Gelvin SB. Expression of the Arabidopsis histone H2A-1 gene correlates with susceptibility to Agrobacterium transformation. Plant J. 2002 Nov;32(3):285-98. PMID:12410808 doi:10.1046/j.1365-313x.2002.01425.x

7bp6, resolution 1.58Å

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OCA
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