6s4l

Structure of human KCTD1Structure of human KCTD1

6s4l is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.42Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

KCTD1_HUMAN Scalp-ear-nipple syndrome. The disease is caused by mutations affecting the gene represented in this entry.

KCTD1_HUMAN May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent.^[1] ^[2]

↑ Ding XF, Luo C, Ren KQ, Zhang J, Zhou JL, Hu X, Liu RS, Wang Y, Gao X, Zhang J. Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions. DNA Cell Biol. 2008 May;27(5):257-65. doi: 10.1089/dna.2007.0662. PMID:18358072 doi:http://dx.doi.org/10.1089/dna.2007.0662
↑ Ding X, Luo C, Zhou J, Zhong Y, Hu X, Zhou F, Ren K, Gan L, He A, Zhu J, Gao X, Zhang J. The interaction of KCTD1 with transcription factor AP-2alpha inhibits its transactivation. J Cell Biochem. 2009 Feb 1;106(2):285-95. doi: 10.1002/jcb.22002. PMID:19115315 doi:http://dx.doi.org/10.1002/jcb.22002