6pvq

Cryo-EM structure of mouse TRPV3-Y564A in intermediate state at 37 degrees CelsiusCryo-EM structure of mouse TRPV3-Y564A in intermediate state at 37 degrees Celsius

6pvq, resolution 4.75Å Show:Asymmetric Unit Biological Assembly Structural highlights 6pvq is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 4.75Å Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function TRPV3_MOUSE Putative receptor-activated non-selective calcium permeant cation channel. It is activated by innocuous (warm) temperatures and shows an increased response at noxious temperatures greater than 39 degrees Celsius. Activation exhibits an outward rectification. May associate with TRPV1 and may modulate its activity. Is a negative regulator of hair growth and cycling: TRPV3-coupled signaling suppresses keratinocyte proliferation in hair follicles and induces apoptosis and premature hair follicle regression (catagen) (By similarity). See Also Ion channels 3D structures